A biomaterial scaffold for regenerating the oral mucosa

用于再生口腔粘膜的生物材料支架

Abstract

本发明涉及一种用于制备生物材料支架的方法,所述方法包括:(a)提供包含纤维蛋白网络和多糖网络的水凝胶;(b)使步骤a)的水凝胶经受冻融过程以物理交联水凝胶;和(c)将在进行步骤b)之后获得的物理交联的水凝胶进行冻干。本发明还涉及通过如上文所定义的方法可获得的生物材料支架以及用于部分或完全增加、恢复或替代患病或损伤的口腔粘膜的功能活性的用途的所述生物材料支架。
The present invention refers to a process for preparing a biomaterial scaffold said method comprising, (a) providing a hydrogel comprising a fibrin network and a polysaccharide network; (b) subjecting the hydrogel of step a) to a freeze-thawing process to physically crosslink the hydrogel; and (c) subjecting the physically cross-linked hydrogel obtained after conducting the step b), to a lyophilization. The invention also relates to the biomaterial scaffold obtainable by the process as defined above, as well said biomaterial scaffold for its use to partially or completely increase, restore or replace the functional activity of a diseased or damaged oral mucosa.

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